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Single doses of XELODA were not lethal to miceratsand monkeys at doses up to 2000 mg/kg2.44.8and 9.6 times the recommended human daily dose on a mg/m 2 basis

Surgery and radiation therapy for breast cancer are classified as local treatments since they are focused on treating the cancer without harming the rest of the bodywhile systemic treatmentslike chemotherapyhormone therapytargeted therapyand bone-directed therapyare focused on the use of drugs to reach and destroy cancer cells in the body.

The first trial was conducted in 22 pediatric patientsmedian age 8 yearsrange 5-17 yearswith newly diagnosed non-disseminated intrinsic diffuse brainstem gliomas and high grade gliomasIn the dosefinding portion of the trialpatients received capecitabine with concomitant radiation therapy at doses ranging from 500 mg/m 2 to 850 mg/m 2 every 12 hours for up to 9 weeksAfter a 2 week breakpatients received 1250 mg/m 2 capecitabine every 12 hours on Days 1-14 of a 21-day cycle for up to 3 cyclesThe maximum tolerated doseMTDof capecitabine administered concomitantly with radiation therapy was 650 mg/m 2 every 12 hoursThe major dose limiting toxicities were palmar-plantar erythrodysesthesia and alanine aminotransferaseALTelevation.

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when taking xeloda, try to stay hydrated by drinking more water than you are used to, doctors often recommend you drink two to three quarts of water every 24 hours.

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