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Men treated with cyclophosphamide may develop oligospermia or azoospermia associated with increased gonadotropin but normal testosterone secretionSexual potency and libido are unimpaired in these patientsBoys treated with cyclophosphamide during prepubescence develop secondary sexual characteristics normallybut may have oligospermia or azoospermia and increased gonadotropin secretionSome degree of testicular atrophy may occurCyclophosphamide-induced azoospermia is reversible in some patientsthough the reversibility may not occur for several years after cessation of therapyMen temporarily rendered sterile by cyclophosphamide have subsequently fathered normal children.

Do not have immunizations/vaccinations without the consent of your doctorAvoid contact with people who have recently received live vaccinessuch as flu vaccine inhaled through the nose

The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.

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