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If you have liver disease or a history of prostate canceryou may need a dose adjustment or special tests to safely take doxazosin.

As with any drug wholly metabolised by the liverCardura should be administered with particular caution to patients with evidence of impaired hepatic functionsee section 4.2Since there is no clinical experience in patients with severe hepatic impairment use in these patients is not recommended.

In relation with the alpha-blocking properties of doxazosinpatients may experience postural hypotension evidenced by dizziness and weaknessor rarely loss of consciousnesssyncopeparticularly with the commencement of therapyThereforeit is prudent medical practice to monitor blood pressure on initiation of therapy to minimise the potential for postural effects.

Patients with renal impairmen tSince there is no change in pharmacokinetics in patients with impaired renal functionthe usual adult dose of Cardura is recommended.

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